1/6/2024 0 Comments Mpv blood work![]() To compare MVP between day 1, day 2, and day 3, Friedman test of repeated measures (> 2 repetitions) was used. Chi-square test was applied for categorical variables, for quantitative variables Mann-Whitney test was used since they show significance in the normality tests (Kolmogorov-Smirnov). Bivariate analyzes were performed to compare the clinical characteristics and laboratory parameters between non-survivors and survivors. Absolute and relative values of the qualitative variables, as well as measures of central tendency and variability for the quantitative variables, were reported. Statistical analyzes were carried out with R software. MPV was measured by impedance in a Siemens 21–20 machine, in venous blood collected in EDTA tubes. The mortality outcome was documented on day 28. The clinical severity of sepsis was estimated by the presence of septic shock and multiple organ dysfunction (SOFA) score. ![]() The MPV and MPV/P ratio were measured upon admission to intensive care on days 1, 2, and 3. From the clinical history, age, sex, site of infection, platelet count, leukocyte count, procalcitonin, and serum lactate were documented. ![]() Patients with non-infectious diseases that report increment of MPV such as acute ischemic heart disease, acute embolic cerebrovascular disease, chronic hematological diseases and who received platelets transfusion during hospitalization were excluded. Patients over 18 years of age with a diagnosis of sepsis under the SEPSIS-3 septic shock criteria were included. The objective of this study is to demonstrate the usefulness of the MPV and mean platelet volume-to-platelet count (MPV/P) ratio as predictors of mortality and severity in patients with sepsis.Īn observational analytical prospective study was carried out at the Intensive Care Unit of Pablo Arturo Suárez Hospital in Quito-Ecuador, to consecutively enroll patients with the diagnosis of sepsis from bacterial origin, from April 2017 to August 2019. The MPV measured in femtoliters (fL) and the coefficient (ratio) between the MPV and the absolute platelet count are anatomical biomarkers derived from platelets, rarely used, but reported in routine blood counts, are gaining interest as markers of evolution to multiple organ dysfunction, clinical severity, and mortality in septic states. In sepsis, a low platelet count is a well-known indicator of poor prognosis. Platelets activated by immunoglobulin, thrombin, collagen, or phorbol myristate acetate (PMA) can also release free mitochondria that behave in a damage-associated molecular pattern that amplifies the inflammatory response. They activate the NLRP3 inflammasome in immune cells, which induces the expression of IL-1. These platelets are morphologically different in shape (spherical with pseudopods) and size (larger), but functionally poorly competent, inducing thrombogenic activity and adverse clinical outcomes. The reason why the platelet, and strictly the mean platelet volume (MPV) marked the biological behavior of sepsis is that the inflammation caused by infectious pathogens induces a systemic response with the production of pro-inflammatory cytokines, thrombopoietin, and other substances that stimulate the massive production of young platelets. It has been shown that coagulation and platelet activation can occur in an early phase of this syndrome, playing a decisive role in its pathophysiology. The hemostatic system is not an exception and is frequently disturbed. It is considered a systemic process with a high probability of organic impact. Sepsis is a dysregulated response of the body to infectious disease, of high prevalence, and in which few measures have not been able to reduce its mortality, except for the early initiation of antibiotic therapy and adequate support for organ failure. The Central University of Ecuador will cover the publication fees in case the manuscript be accepted.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting Information files.įunding: The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Received: MaAccepted: DecemPublished: January 6, 2022Ĭopyright: © 2022 Vélez-Páez et al. PLoS ONE 17(1):Įditor: Andrea Ballotta, IRCCS Policlinico S.Donato, ITALY (2022) Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis. Citation: Vélez-Páez JL, Legua P, Vélez-Páez P, Irigoyen E, Andrade H, Jara A, et al.
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